СУКЦИНИЛ-
ПОЛУАЛЬДЕГИД
СУКЦИНА
Т (ЯНТАРНАЯ К.)
ФУМАРА
Т (т)
МАЛЕА
Т (ц)
МАЛА
Т (ЯБЛОЧНАЯ К.)
ОКСАЛОАЦЕТАТ2-ОКСОГЛУТАРАТ
МЕТИЛОКСАЛОАЦЕТАТ
ИЗОЦИТРАМАЛАТ
МЕЗАКОНА
Т (т)
ЦИТРАКОНА
Т (ц)
цис-АКОНИТАТ
/транс-АКОНИТАТ
ИЗОЦИТРАТ
ОКСАЛОСУКЦИНАТ
2-МЕТИЛЦИТР
А
Т
Рис. 8. Цикл лимонной кисл
о
ты (а) и пре
дполаг
аемые реакции гипо
тетическог
о цикла метиллимонной кисл
о
ты (б).
(б)(а)
ЦИТР
А
Т (ЛИМОННАЯ К.)
H
2
CCOOH
H
2
C
HCO/TPP
?
CO
2
CO
2
H
2
CCOOH//Lip
H
2
CCOOH/CoA
6.2.1.4/M3.1.2.1/M2.8.3.2/
6.2.1.5/M3.1.2.3/M2.8.3.5/M
?
HCCOOH
HOOCCH
5.2.1.1C-T
H
3
C
CCOOH
HOOCCH
H
2
CCOOH/CoA
HOCCOOH
6.2.1.9/
H
H
3
C
HCCOOH
HOCCOOH
H
H
2
CCOOH
OCCOOH
H
3
C
HCCOOH
OCCOOH
H
2
CCOOH
H
2
C
OCCOOH
?
CO
2
CO
2
(Ac)
AcCoA
AcCoAH
2
CCOOH
CCOOH
HCCOOH
5.3.3.7C-T
?
H
2
CCOOH
HOCCOOH
H
2
CCOOH/CoA
6.2.1.18/SM
H
2
CCOOH
HOCCOOH
HCCOOH
CH
3
H
2
CCOOH
HCCOOH
HOCCOOH
H
5.1.2.6R-S
?
H
2
CCOOH
HCCOOH
OCCOOH
?
1.2.1.16
1.2.1.24M
*/1.2.4.2//M
*/1.2.7.3/
*/1.2.4.2M
*/1.2.7.3
1.3.5.1T
1.3.99.1TM
4.2.1.2S-TM
4.2.1.31R-CM
4.2.1.34S-T
1.1.1.37SM
1.1.1.82S
1.1.3.3S
1.1.99.7S
1.1.99.16S
(4.1.3.6)
4.1.3.7M
4.1.3.8M
4.1.3.28
4.1.3.34/
1.1.1.41*RM
1.1.1.42*
4.2.1.3CM
4.2.1.4C
4.2.1.3
C
M
1.1.1.41*RM
1.1.1.42*R
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